Top 31 Biological Laboratory Technician Interview Questions and Answers [Updated 2025]

Author

Andre Mendes

March 30, 2025

Embarking on a career as a Biological Laboratory Technician? This post is your ultimate guide to acing the interview! Dive into the most common questions you'll encounter and discover insightful example answers along with practical tips to help you respond effectively. Whether you're a seasoned professional or a newcomer, this resource is designed to boost your confidence and prepare you for success in your next interview.

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List of Biological Laboratory Technician Interview Questions

Situational Interview Questions

ETHICS

You discover that data from an experiment has been misrepresented. What actions would you take upon this discovery?

How to Answer

  1. 1

    Assess the nature and extent of the misrepresentation

  2. 2

    Document the findings and evidence clearly

  3. 3

    Report the issue to your supervisor or lead scientist

  4. 4

    Suggest corrective actions to address the misrepresented data

  5. 5

    Follow up to ensure the issue is resolved and transparently communicated

Example Answers

1

I would first review the data to understand how it was misrepresented. Then, I'd document my findings and report it to my supervisor immediately. It's important to suggest ways to correct the data to maintain integrity in our research.

EMERGENCY RESPONSE

You find that a chemical spill has occurred in the lab. What steps would you take to manage the situation?

How to Answer

  1. 1

    Immediately alert your supervisor and other colleagues to the spill.

  2. 2

    Assess the size and nature of the spill to determine necessary cleanup procedures.

  3. 3

    Put on appropriate personal protective equipment (PPE) for safety.

  4. 4

    Use spill kits or containment materials to contain or neutralize the spill.

  5. 5

    Follow lab protocols for reporting and documenting the incident.

Example Answers

1

First, I would alert my supervisor and colleagues about the spill. Then, I would assess the situation to determine if it's safe to approach. After wearing the appropriate PPE, I'd use the spill kit to contain the spill and follow up by documenting the incident as per lab procedures.

INTERACTIVE PRACTICE
READING ISN'T ENOUGH

Don't Just Read Biological Laboratory Technician Questions - Practice Answering Them!

Reading helps, but actual practice is what gets you hired. Our AI feedback system helps you improve your Biological Laboratory Technician interview answers in real-time.

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EXPERIMENTAL FAILURE

Imagine an experiment you are conducting consistently yields unexpected results. How would you troubleshoot and proceed?

How to Answer

  1. 1

    Review the experimental design for potential flaws or assumptions.

  2. 2

    Examine the materials and reagents used for expiration or contamination.

  3. 3

    Repeat the experiment to confirm the unexpected results are consistent.

  4. 4

    Consult relevant literature and colleagues for insights on similar issues.

  5. 5

    Document all findings meticulously to track patterns or anomalies.

Example Answers

1

I would start by reviewing the experimental design to check for any assumptions that might be incorrect. Then, I would examine the reagents for any signs of contamination. If the unexpected results persist, I would repeat the experiment to confirm the findings and possibly consult with colleagues for advice.

EQUIPMENT MALFUNCTION

You are working on a critical experiment when the spectrophotometer stops functioning. What actions would you take?

How to Answer

  1. 1

    Check the power source and connections to ensure the device is plugged in and functioning correctly.

  2. 2

    Review the user manual for troubleshooting steps specific to your model.

  3. 3

    Run a self-diagnostic test if available on the spectrophotometer.

  4. 4

    Contact a colleague or supervisor for assistance or to provide input on the issue.

  5. 5

    Document the issue and the steps taken for future reference.

Example Answers

1

First, I would check the power source and ensure the spectrophotometer is plugged in properly. If it's powered, I'd consult the manual for troubleshooting tips. If the problem persists, I would run a self-diagnostic test and reach out to my supervisor for further assistance.

PROTOCOL DEVELOPMENT

You are tasked with developing a new protocol for a series of experiments. How would you approach this task?

How to Answer

  1. 1

    Define the objective and goals of the experiments clearly.

  2. 2

    Conduct a thorough literature review to find existing protocols.

  3. 3

    Identify the materials and methods required for the protocol.

  4. 4

    Draft the protocol step-by-step, ensuring clarity and precision.

  5. 5

    Plan for troubleshooting and include safety precautions.

Example Answers

1

I would start by clearly defining the specific goals of the experiments, then review existing literature to gather information on similar protocols. This would help me identify necessary materials and draft a step-by-step procedure, ensuring I include troubleshooting tips and safety measures.

PRIORITIZATION

If you have multiple tasks to complete, including urgent sample analysis and routine maintenance, how would you prioritize your work?

How to Answer

  1. 1

    Assess urgency of tasks based on deadlines and consequences.

  2. 2

    Categorize tasks into urgent and non-urgent.

  3. 3

    Allocate time for high-priority tasks first.

  4. 4

    Communicate with your team about your priorities.

  5. 5

    Plan for routine tasks during low-activity periods.

Example Answers

1

I would start by identifying which tasks are most urgent, like any pending sample analyses that have strict deadlines. Then I would focus on those first, while scheduling routine maintenance during quieter times later in the day.

COLLABORATION

A senior scientist requests your assistance with a high-priority research project that conflicts with your current tasks. How would you handle the situation?

How to Answer

  1. 1

    Assess the priority of the senior scientist's request.

  2. 2

    Communicate openly about your current workload.

  3. 3

    Explore options for collaboration or assistance.

  4. 4

    Suggest a timeline for when you can assist.

  5. 5

    Stay flexible and willing to adjust your tasks if necessary.

Example Answers

1

I would first evaluate how urgent the senior scientist's project is compared to my current tasks. If it is indeed a high priority, I would discuss my current workload with them to see if we can find a compromise, such as adjusting deadlines or allocating some time for their project while keeping my responsibilities in check.

REPORT GENERATION

You need to present your findings from a series of experiments to a cross-functional team. How would you prepare and communicate your results?

How to Answer

  1. 1

    Understand your audience's background and knowledge

  2. 2

    Summarize key findings and their implications

  3. 3

    Use visuals like charts and graphs to illustrate results

  4. 4

    Practice your presentation to be clear and confident

  5. 5

    Prepare for questions and be ready to discuss details

Example Answers

1

I would first assess the knowledge level of the team to tailor my presentation accordingly. Then, I would summarize the main findings and highlight their implications for our projects. Visual aids like graphs would help convey complex data effectively. I would practice my delivery to ensure clarity and anticipate potential questions.

COMMUNICATION

A team member is not following safety protocols, potentially causing risks. How would you address this issue?

How to Answer

  1. 1

    Identify the specific safety protocol they are violating

  2. 2

    Approach the team member privately and express your concerns respectfully

  3. 3

    Explain the importance of the protocol in relation to safety and well-being

  4. 4

    Offer help or resources if they are unsure about the protocols

  5. 5

    If necessary, escalate the issue to a supervisor if the behavior does not change

Example Answers

1

I would first take note of the specific protocol they're not following. Then, I would approach them privately to discuss my concerns, emphasizing why following safety protocols is crucial for everyone's well-being. I'd offer to help if they need clarification on the procedures.

QUALITY CONTROL

During a quality control check, you find that a batch of reagents is contaminated. What steps would you take to resolve this?

How to Answer

  1. 1

    Identify and isolate the contaminated batch immediately

  2. 2

    Document the contamination and any relevant details

  3. 3

    Notify your supervisor and the quality control team

  4. 4

    Assess the cause of contamination to prevent future occurrences

  5. 5

    Dispose of the contaminated batch following safety guidelines

Example Answers

1

I would first isolate the contaminated batch to prevent any further use. Then, I would document my findings and notify my supervisor. After that, I’d investigate the source of contamination and ensure that we dispose of the reagents safely.

INTERACTIVE PRACTICE
READING ISN'T ENOUGH

Don't Just Read Biological Laboratory Technician Questions - Practice Answering Them!

Reading helps, but actual practice is what gets you hired. Our AI feedback system helps you improve your Biological Laboratory Technician interview answers in real-time.

Master your interview answers under pressure

Boost your confidence with real-time practice

Speak clearly and impress hiring managers

Get hired faster with focused preparation

Used by hundreds of successful candidates

RESOURCE MANAGEMENT

The lab is running low on critical supplies, but the budget for the month is exhausted. How would you handle this situation?

How to Answer

  1. 1

    Assess the urgency of the supplies needed

  2. 2

    Identify alternative solutions such as reallocation or sharing resources

  3. 3

    Communicate with the supervisor about the situation and potential options

  4. 4

    Document the issue and rationale for any emergency requests

  5. 5

    Plan ahead for future budgeting by tracking supply usage

Example Answers

1

I would first evaluate which supplies are absolutely critical and needed immediately. Then, I would explore if we could temporarily borrow supplies from another lab or department. After that, I would inform my supervisor and discuss how we might address the budget constraints moving forward.

Behavioral Interview Questions

TEAMWORK

Describe a situation where you had to collaborate with a team to complete a laboratory project. What was your role and the outcome?

How to Answer

  1. 1

    Select a specific project you worked on with a team

  2. 2

    Clearly define your role in the team

  3. 3

    Highlight how you contributed to the team's success

  4. 4

    Mention any challenges faced and how you overcame them

  5. 5

    Describe the final outcome and what you learned from the experience

Example Answers

1

In my last semester, I worked on a team project analyzing the effects of pH levels on bacterial growth. I was responsible for preparing the agar plates and ensuring proper sterile techniques. Our team faced contamination issues, but by collaborating closely, we revised our protocols and successfully completed the project, achieving significant data on growth rates across different pH levels.

ATTENTION TO DETAIL

Give an example of a time when your attention to detail prevented an error in the lab.

How to Answer

  1. 1

    Think of a specific lab situation where you had to focus on details.

  2. 2

    Describe the error that could have occurred without your attention.

  3. 3

    Explain the steps you took to ensure accuracy in your work.

  4. 4

    Highlight the positive outcome of your careful approach.

  5. 5

    Use the STAR method: Situation, Task, Action, Result.

Example Answers

1

In my last lab internship, I was measuring reagents for an experiment. I noticed a miscalculation in the concentration that could have skewed our results. I double-checked my measurements and recalibrated the pipettes before proceeding. Thanks to this attention to detail, we obtained accurate results that were critical for our study.

INTERACTIVE PRACTICE
READING ISN'T ENOUGH

Don't Just Read Biological Laboratory Technician Questions - Practice Answering Them!

Reading helps, but actual practice is what gets you hired. Our AI feedback system helps you improve your Biological Laboratory Technician interview answers in real-time.

Master your interview answers under pressure

Boost your confidence with real-time practice

Speak clearly and impress hiring managers

Get hired faster with focused preparation

Used by hundreds of successful candidates

PROBLEM-SOLVING

Tell me about a challenging problem you faced in the laboratory. How did you solve it?

How to Answer

  1. 1

    Start with a specific problem you encountered.

  2. 2

    Explain the context of the problem briefly.

  3. 3

    Describe the steps you took to resolve the issue.

  4. 4

    Highlight any teamwork or collaboration involved.

  5. 5

    Conclude with the outcome and what you learned.

Example Answers

1

In my previous role, I faced a situation where a critical experiment was yielding inconsistent results. I investigated the protocols and realized there was a temperature fluctuation in the incubator. I recalibrated the equipment and reran the experiment, ensuring proper controls. This led to consistent results and improved our data reliability.

ADAPTABILITY

Describe a time when you had to adapt to a significant change in the laboratory procedures or protocols. How did you handle it?

How to Answer

  1. 1

    Use the STAR method: Situation, Task, Action, Result

  2. 2

    Clearly outline the change in procedures you faced

  3. 3

    Describe your specific role in adapting to the change

  4. 4

    Emphasize any positive outcomes or lessons learned

  5. 5

    Keep your answer focused and concise

Example Answers

1

In my previous lab, we switched from manual pipetting to an automated system. I was tasked with learning the new equipment quickly. I set up training sessions and practiced using the automation software for two weeks. This not only enhanced my skills but also improved our efficiency by 20%.

TIME MANAGEMENT

How do you prioritize your tasks in a busy laboratory environment? Can you give an example of how you managed your time effectively?

How to Answer

  1. 1

    Identify urgent tasks versus important tasks

  2. 2

    Use a daily or weekly checklist to track tasks

  3. 3

    Communicate with your team about priority changes

  4. 4

    Break larger tasks into smaller, manageable steps

  5. 5

    Reflect on completed tasks to improve future prioritization

Example Answers

1

In my previous role, I faced a situation where I had to process multiple samples while preparing for an audit. I prioritized urgent sample processing first by creating a checklist, then allocated specific time blocks for audit preparation. This approach ensured I met both deadlines efficiently.

CONFLICT RESOLUTION

Tell me about a time you disagreed with a colleague on a laboratory procedure. How did you resolve the disagreement?

How to Answer

  1. 1

    Describe the situation clearly and specifically.

  2. 2

    Explain the nature of the disagreement without assigning blame.

  3. 3

    Highlight your communication approach and how you listened to their perspective.

  4. 4

    Discuss the resolution and any compromises made.

  5. 5

    Convey what you learned from the experience.

Example Answers

1

In a previous lab, I disagreed with a colleague on the correct dilution method for a reagent. I suggested we review the standard operating procedures together. We each presented our reasoning, and after discussing the data, we agreed on a modified approach that incorporated both suggestions. This improved our results and strengthened our teamwork.

LEARNING AND DEVELOPMENT

Can you describe a time when you had to learn a new laboratory technique quickly? How did you accomplish this?

How to Answer

  1. 1

    Identify a specific technique you learned under pressure

  2. 2

    Highlight your approach to learning swiftly

  3. 3

    Discuss resources you used, such as manuals or videos

  4. 4

    Emphasize teamwork or asking colleagues for help

  5. 5

    Reflect on the outcome and what you learned from the experience

Example Answers

1

In my last internship, I had to learn PCR quickly for a project. I devoted the first two hours to reviewing the protocol and watched instructional videos online. I also asked a colleague for a brief demonstration. By the end of the day, I successfully ran my first PCR experiment, which came out correctly.

INITIATIVE

Give an example of when you went above and beyond your regular duties to improve the lab's operation.

How to Answer

  1. 1

    Think of a specific instance where you took initiative.

  2. 2

    Focus on the impact of your actions on the lab and team.

  3. 3

    Quantify any improvements if possible, such as time saved or efficiency gained.

  4. 4

    Use the STAR method: Situation, Task, Action, Result.

  5. 5

    Show how your actions align with the lab's goals or values.

Example Answers

1

In my previous role, we faced delays in receiving test results. I volunteered to create a tracking system using spreadsheets, which improved our turnaround time by 30%. This allowed researchers to access their results faster, enhancing overall lab productivity.

PRECISION

Tell me about a situation where precision was particularly important in your work. How did you ensure high standards were maintained?

How to Answer

  1. 1

    Identify a specific situation where precision was critical.

  2. 2

    Describe the specific steps you took to ensure accuracy.

  3. 3

    Mention tools or techniques that helped you maintain precision.

  4. 4

    Highlight the outcome of your approach and its impact.

  5. 5

    Emphasize your attention to detail and commitment to standards.

Example Answers

1

In my previous role, I worked on a project involving DNA extraction where precision was crucial for reliable results. I meticulously followed the protocol step-by-step, double-checked all measurements using calibrated pipettes, and kept a detailed log of every action. This careful approach ensured that our results were accurate and reproducible, which was vital for the subsequent experiments.

RESEARCH CONTRIBUTION

Describe a research project you contributed to. What was your role and how did your contributions impact the project?

How to Answer

  1. 1

    Choose a specific research project that highlights your skills.

  2. 2

    Clearly define your role and responsibilities in the project.

  3. 3

    Emphasize the specific techniques or methods you used.

  4. 4

    Discuss the impact of your contributions on the project's outcomes.

  5. 5

    Relate the experience to the skills required for the job you're applying for.

Example Answers

1

I worked on a project examining the effects of a new antibiotic. As a lab technician, I was responsible for preparing cultures and conducting sensitivity tests. My thorough testing procedures helped identify the most effective concentrations, which guided further clinical trials.

INTERACTIVE PRACTICE
READING ISN'T ENOUGH

Don't Just Read Biological Laboratory Technician Questions - Practice Answering Them!

Reading helps, but actual practice is what gets you hired. Our AI feedback system helps you improve your Biological Laboratory Technician interview answers in real-time.

Master your interview answers under pressure

Boost your confidence with real-time practice

Speak clearly and impress hiring managers

Get hired faster with focused preparation

Used by hundreds of successful candidates

Technical Interview Questions

EQUIPMENT HANDLING

What steps do you take to ensure the laboratory equipment is properly calibrated and maintained?

How to Answer

  1. 1

    Familiarize yourself with the manufacturer's calibration and maintenance guidelines

  2. 2

    Schedule regular calibration checks and maintenance appointments on a calendar

  3. 3

    Document all maintenance and calibration activities for future reference

  4. 4

    Perform routine visual inspections to identify any potential issues

  5. 5

    Report any malfunctions or concerns to a supervisor immediately

Example Answers

1

I always follow the manufacturer's guidelines for calibration and ensure I keep a maintenance log. I schedule regular check-ups and visually inspect equipment frequently to catch any issues early.

LABORATORY TECHNIQUES

Can you explain the process of PCR and why it is used in biological research?

How to Answer

  1. 1

    Start by defining PCR and its purpose in amplifying DNA.

  2. 2

    Briefly describe the three main steps of PCR: denaturation, annealing, and extension.

  3. 3

    Mention the role of primers and thermocycling in the process.

  4. 4

    Highlight applications of PCR in research, clinical diagnostics, and forensic science.

  5. 5

    Conclude with its significance in advancing biological research.

Example Answers

1

PCR, or Polymerase Chain Reaction, is a technique used to amplify specific DNA sequences. It involves three main steps: first, denaturation of the DNA template at a high temperature; second, annealing where primers attach to the target sequence; and third, extension where DNA polymerase synthesizes new DNA strands. PCR is important for applications like disease detection and genetic research, making it a cornerstone in molecular biology.

INTERACTIVE PRACTICE
READING ISN'T ENOUGH

Don't Just Read Biological Laboratory Technician Questions - Practice Answering Them!

Reading helps, but actual practice is what gets you hired. Our AI feedback system helps you improve your Biological Laboratory Technician interview answers in real-time.

Master your interview answers under pressure

Boost your confidence with real-time practice

Speak clearly and impress hiring managers

Get hired faster with focused preparation

Used by hundreds of successful candidates

DATA ANALYSIS

How do you ensure the accuracy and reliability of data collected in experiments?

How to Answer

  1. 1

    Always use calibrated equipment and verify its accuracy before experiments

  2. 2

    Implement consistent protocols and standard operating procedures for all experiments

  3. 3

    Perform replications of experiments to confirm results and identify potential errors

  4. 4

    Document all processes and anomalies to provide context for the data collected

  5. 5

    Regularly review data with peers to cross-verify findings and enhance reliability

Example Answers

1

I ensure accuracy by using calibrated equipment and following strict protocols for each experiment. Additionally, I replicate critical experiments to confirm results.

SAFETY

What safety measures do you follow to ensure a safe working environment in the laboratory?

How to Answer

  1. 1

    Always wear appropriate personal protective equipment like gloves and lab coats.

  2. 2

    Know the location and proper use of safety equipment such as eyewash stations and fire extinguishers.

  3. 3

    Follow proper protocols for handling hazardous materials and dispose of waste correctly.

  4. 4

    Keep workspaces tidy to avoid accidents and ensure clear access to exits.

  5. 5

    Stay updated on safety training and emergency procedures relevant to your specific laboratory.

Example Answers

1

I always wear gloves and a lab coat to protect myself from contaminants. Also, I am familiar with the locations of the eyewash stations and emergency showers in case of spills.

SOFTWARE PROFICIENCY

What laboratory software are you proficient in, and how have you used it in the past?

How to Answer

  1. 1

    Identify key laboratory software relevant to the position.

  2. 2

    Explain your level of proficiency (beginner, intermediate, advanced).

  3. 3

    Provide specific examples of tasks you completed using the software.

  4. 4

    Mention any outcomes or improvements resulting from your use of the software.

  5. 5

    Tailor your answer to the job description and required skills.

Example Answers

1

I am proficient in ELN (Electronic Lab Notebook) software, specifically LabArchives. I have used it to document experimental procedures and results, which improved my team’s data retrieval time by 30%.

SPECIMEN HANDLING

Describe the proper procedures for handling biological specimens to prevent contamination.

How to Answer

  1. 1

    Always wear appropriate personal protective equipment, such as gloves and lab coats.

  2. 2

    Use sterile containers and tools to collect and store specimens.

  3. 3

    Work in a designated biosafety cabinet when handling infectious materials.

  4. 4

    Label specimens clearly and securely to avoid mix-ups.

  5. 5

    Dispose of waste following institutional biohazard waste protocols.

Example Answers

1

To prevent contamination, I always wear gloves and a lab coat, and use sterile containers for specimens. I handle samples within a biosafety cabinet to minimize exposure to airborne contaminants.

MICROSCOPY

What are the key differences between light microscopy and electron microscopy?

How to Answer

  1. 1

    Focus on the main principles of each microscopy type

  2. 2

    Mention the levels of magnification achievable

  3. 3

    Discuss the types of samples each method can examine

  4. 4

    Include the speed and ease of use comparison

  5. 5

    Address the costs and accessibility of the techniques

Example Answers

1

Light microscopy uses visible light to magnify samples, allowing for quick examination at lower magnifications, while electron microscopy uses electrons for much higher magnifications but is more complex and slower.

MOLECULAR BIOLOGY

How would you use gel electrophoresis to analyze DNA samples?

How to Answer

  1. 1

    Describe the preparation of the DNA samples before running the gel.

  2. 2

    Explain the setup of the gel electrophoresis apparatus including the buffer solution.

  3. 3

    Discuss how to load the DNA samples into the wells of the gel.

  4. 4

    Mention how to run the gel and what electrical voltage to apply.

  5. 5

    Talk about visualizing the results and analyzing the DNA bands.

Example Answers

1

To analyze DNA samples using gel electrophoresis, I would first prepare the DNA samples by mixing them with a loading dye for visibility. Next, I would set up the gel in the electrophoresis chamber, ensuring the agarose gel is submerged in an appropriate buffer solution. I would then carefully load the samples into the wells, and run the gel at a voltage of around 100 volts. Finally, I would visualize the DNA bands using a staining solution and analyze the sizes of the bands against a DNA ladder.

DOCUMENTATION

How do you ensure accurate and complete documentation of laboratory procedures and results?

How to Answer

  1. 1

    Follow standardized protocols for documentation consistency

  2. 2

    Use clear, precise language and avoid jargon

  3. 3

    Double-check entries for accuracy before finalizing

  4. 4

    Date and initial each entry to maintain accountability

  5. 5

    Utilize templates or digital tools to improve efficiency

Example Answers

1

I follow standardized protocols for documentation to maintain consistency. I always use clear language and double-check my entries before finalizing to ensure accuracy.

CELL CULTURE

What are the key considerations when maintaining cell cultures in the laboratory?

How to Answer

  1. 1

    Ensure sterile techniques to prevent contamination.

  2. 2

    Control temperature and CO2 levels consistently.

  3. 3

    Regularly check the pH of the culture medium.

  4. 4

    Passage cells at appropriate intervals to prevent over-confluence.

  5. 5

    Monitor for signs of contamination or cell death regularly.

Example Answers

1

Key considerations include using sterile techniques to avoid contamination, maintaining consistent temperature and CO2 levels, and monitoring the pH of the medium regularly.

INTERACTIVE PRACTICE
READING ISN'T ENOUGH

Don't Just Read Biological Laboratory Technician Questions - Practice Answering Them!

Reading helps, but actual practice is what gets you hired. Our AI feedback system helps you improve your Biological Laboratory Technician interview answers in real-time.

Master your interview answers under pressure

Boost your confidence with real-time practice

Speak clearly and impress hiring managers

Get hired faster with focused preparation

Used by hundreds of successful candidates

PREMIUM

Ace Your Next Interview!

Master your interview answers under pressure

Boost your confidence with real-time practice

Speak clearly and impress hiring managers

Get hired faster with focused preparation

Used by hundreds of successful candidates

PREMIUM

Ace Your Next Interview!

Master your interview answers under pressure

Boost your confidence with real-time practice

Speak clearly and impress hiring managers

Get hired faster with focused preparation

Used by hundreds of successful candidates